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P62-mediated mitophagy inducer
CAS No. 1809031-84-2
P62-mediated mitophagy inducer( PMI )
Catalog No. M12772 CAS No. 1809031-84-2
P62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway; induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes; increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy; disrupts the Nrf2-Keap1 interaction.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 35 | Get Quote |
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| 5MG | 58 | Get Quote |
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| 10MG | 87 | Get Quote |
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| 25MG | 192 | Get Quote |
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| 50MG | 312 | Get Quote |
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| 100MG | 500 | Get Quote |
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| 200MG | 710 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameP62-mediated mitophagy inducer
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NoteResearch use only, not for human use.
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Brief DescriptionP62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway; induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes; increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy; disrupts the Nrf2-Keap1 interaction.
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DescriptionP62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway; induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes; increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy; disrupts the Nrf2-Keap1 interaction.
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In VitroP62-mediated mitophagy inducer (10 μM; 0, 1, 3, 6, 24 h) stabilizes Nrf2 and (10 μM; 9 h) upregulates P62 expression activating mitophagy.P62-mediated mitophagy (10 μM; 24 h) acts downstream of the PINK1/Parkin signaling pathway in MEFs.P62-mediated mitophagy inducer positively affects mitochondrial poly-ubiquitination and coupling. RT-PCR Cell Line:MEFs Concentration:10 μM Incubation Time:9 h Result:Significantly increased p62 mRNA levels.Immunofluorescence Cell Line:MEFs Concentration:10 μM Incubation Time:24 h Result:Demonstrated Parkin-independent induction of mitochondrial recruitment of P62.Western Blot Analysis Cell Line:MEFs Concentration:10 μM Incubation Time:0, 1, 3, 6, 24 h Result:Exhibited maximum Nrf2 levels after 6 h and remained elevated at 24 h.
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In Vivo——
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SynonymsPMI
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PathwayAutophagy
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TargetMitophagy
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RecptorMitophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number1809031-84-2
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Formula Weight392.156
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Molecular FormulaC14H9IN4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 8.33 mg/mL (21.24 mM)
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SMILESC1=CC(=CC(=C1)[N+](=O)[O-])C2=CN(N=N2)C3=CC(=CC=C3)I
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Chemical Name1-(3-iodophenyl)-4-(3-nitrophenyl)-1H-1,2,3-triazole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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P62-mediated mitopha...
P62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway; induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes; increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy; disrupts the Nrf2-Keap1 interaction.
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Mtphagy Dye
Mtphagy Dye is a small-molecule fluorescent probe for visualizing mitophagy; has suitable fluorescent properties for detecting mitochondrial acidification during mitophagy in the long-wavelength region that does not damage mitochondria.
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U0126
U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhibits autophagy and mitophagy.
