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P62-mediated mitophagy inducer

CAS No. 1809031-84-2

P62-mediated mitophagy inducer( PMI )

Catalog No. M12772 CAS No. 1809031-84-2

P62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway; induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes; increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy; disrupts the Nrf2-Keap1 interaction.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    P62-mediated mitophagy inducer
  • Note
    Research use only, not for human use.
  • Brief Description
    P62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway; induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes; increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy; disrupts the Nrf2-Keap1 interaction.
  • Description
    P62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway; induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes; increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy; disrupts the Nrf2-Keap1 interaction.
  • In Vitro
    P62-mediated mitophagy inducer (10 μM; 0, 1, 3, 6, 24 h) stabilizes Nrf2 and (10 μM; 9 h) upregulates P62 expression activating mitophagy.P62-mediated mitophagy (10 μM; 24 h) acts downstream of the PINK1/Parkin signaling pathway in MEFs.P62-mediated mitophagy inducer positively affects mitochondrial poly-ubiquitination and coupling. RT-PCR Cell Line:MEFs Concentration:10 μM Incubation Time:9 h Result:Significantly increased p62 mRNA levels.Immunofluorescence Cell Line:MEFs Concentration:10 μM Incubation Time:24 h Result:Demonstrated Parkin-independent induction of mitochondrial recruitment of P62.Western Blot Analysis Cell Line:MEFs Concentration:10 μM Incubation Time:0, 1, 3, 6, 24 h Result:Exhibited maximum Nrf2 levels after 6 h and remained elevated at 24 h.
  • In Vivo
    ——
  • Synonyms
    PMI
  • Pathway
    Autophagy
  • Target
    Mitophagy
  • Recptor
    Mitophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1809031-84-2
  • Formula Weight
    392.156
  • Molecular Formula
    C14H9IN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 8.33 mg/mL (21.24 mM)
  • SMILES
    C1=CC(=CC(=C1)[N+](=O)[O-])C2=CN(N=N2)C3=CC(=CC=C3)I
  • Chemical Name
    1-(3-iodophenyl)-4-(3-nitrophenyl)-1H-1,2,3-triazole

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. East DA, et al. Chem Biol. 2014 Nov 20;21(11):1585-96. 2. Bertrand HC, et al. J Med Chem. 2015 Sep 24;58(18):7186-94. 3. Holmstr?m KM, et al. Curr Opin Toxicol. 2016 Dec;1:80-91.
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  • P62-mediated mitopha...

    P62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway; induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes; increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy; disrupts the Nrf2-Keap1 interaction.

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